Early life stress induces irritable bowel syndrome from childhood to adulthood in mice.

Enfu Tao,Yuhao Wu,Chenmin Hu,Zhenya Zhu,Diya Ye,Gao Long,Bo Chen, Rui Guo,Xiaoli Shu,Wei Zheng,Ting Zhang,Xinyi Jia,Xiao Du,Marong Fang,Mizu Jiang

Frontiers in microbiology（2023）

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摘要

The study showed for the first time that MS induced IBS from early life to adulthood in mice. The disrupted intestinal mitochondrial structure and the significant dysbiosis of intestinal microbiota in early life may contribute to the initiation and progress of IBS from early life to adulthood.

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irritable bowel syndrome,early life stress,mice,childhood

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