Evaluation of immune infiltrate according to the HER2 status in colorectal cancer

Chloé Molimard, Fanny Dor,Alexis Overs,Franck Monnien, Grégoire Gessain, Loïs Kedochim, Flavia D'Angelo, Marine Abad, Morgane Heberle,Valentin Derangère,François Ghiringhelli,Lucine Vuitton,Séverine Valmary-Degano,Christophe Borg,Zaher Lakkis,Fréderic Bibeau

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver（2023）

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摘要

Our original findings suggest that in pMMR/MSS CRC, the immune infiltrate is reduced in HER2 amplified versus other HER2 categories. These data might be useful for future strategies combining anti-HER2 treatments and immune checkpoint inhibitors and need to be confirmed in larger CRC cohorts.

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关键词

Colorectal cancer,HER2,Immune infiltrate,QuPath software

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