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Effect of elexacaftor/tezacaftor/ivacaftor on mucus and mucociliary clearance in cystic fibrosis

Scott H. Donaldson,Timothy E. Corcoran,Joseph M. Pilewski,Peter Mogayzel,Beth L. Laube,Evan R. Boitet,Elex S. Harris,Agathe Ceppe,Lloyd J. Edwards,Kirby Zeman,Jihong Wu,Charles R. Esther Jr,David P. Nichols,William D. Bennett,Steven M. Rowe

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society（2023）

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Abstract
•Elexacaftor/tezacaftor/ivacaftor increases sputum hydration in cystic fibrosis.•Elexacaftor/tezacaftor/ivacaftor (E/T/I) markedly improves mucociliary clearance.•Exhaled breath condensate pH and sialic acid levels were unchanged after E/T/I.
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Key words
Cystic fibrosis,Mucociliary clearance,Modulator,Elexacaftor,Rheology,mucus
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