Respiratory Function Changes as Early Signs of Amyotrophic Lateral Sclerosis.

Mario Polverino,Simone Sampaolo,Antonio Capuozzo, Marco Fasolino, Michele Aliberti,Ersilia Satta,Carlo Santoriello,James Peter Orengo,Francesca Polverino

Respiration; international review of thoracic diseases（2023）

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摘要

Changes in MIP, P0.1, and P0.1/MIP ratio are highly suggestive of preclinical ALS when the spirometry and neurodiagnostic tests are still inconclusive. MIP and P0.1 are noninvasive measurements that can be easily assessed in an ambulatory setting. Future studies on larger cohorts are needed to validate the use of these parameters in the preclinical diagnosis of ALS as well as in other neuromuscular diseases.

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respiratory function changes,early signs

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