AI/ML Combined with Next-Generation Sequencing of VHH Immune Repertoires Enables the Rapid Identification of De Novo Humanized and Sequence-Optimized Single Domain Antibodies: a Prospective Case Study.

Paul Arras, Han Byul Yoo,Lukas Pekar,Thomas Clarke,Lukas Friedrich,Christian Schroeter,Jennifer Schanz,Jason Tonillo,Vanessa Siegmund,Achim Doerner,Simon Krah, Enrico Guarnera,Stefan Zielonka,Andreas Evers

FRONTIERS IN MOLECULAR BIOSCIENCES（2023）

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artificial intelligence and machine learning (ML),deep learning,in silico developability,long short-term memory (LSTM),next-generation sequencing (NGS),single domain antibodies (VHH),yeast surface display (YSD),protein engineering

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