Macrophage RIPK3 triggers inflammation and cell death via the XBP1-Foxo1 axis in liver ischaemia-reperfusion injury.

Xiaoye Qu,Tao Yang,Xiao Wang,Dongwei Xu,Yeping Yu,Jun Li,Longfeng Jiang,Qiang Xia,Douglas G Farmer,Bibo Ke

JHEP reports : innovation in hepatology（2023）

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摘要

Macrophage RIPK3 promotes NOD1-dependent inflammation and calcineurin/TRPM7-induced cell death cascade by triggering the XBP1-Foxo1 axis and its target gene , which is crucial for activating NOD1 and calcineurin/TRPM7 function, implying the potential therapeutic targets in stress-induced liver inflammatory injury.

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关键词

ER stress,Innate immunity,IRE1α,XBP1,Foxo1,Reactive oxygen species,Necroptosis,Liver inflammation

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