Cytokine dysregulation despite immunoglobulin replacement therapy in common variable immunodeficiency (CVID).

Remo Poto,Antonio Pecoraro,Anne Lise Ferrara,Alessandra Punziano,Gianluca Lagnese, Carla Messuri,Stefania Loffredo,Giuseppe Spadaro,Gilda Varricchi

Frontiers in immunology（2023）

Cited 0|Views6

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Abstract

These findings indicate persistent cytokine dysregulation despite IgRT in individuals with CVID. Moreover, the circulating cytokine profile reveals the heterogeneity of immune dysregulation in different subgroups of CVID subjects.

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Key words

common variable immunodeficiency, CVID, lipopolysaccharide, IL-1, TNF-alpha, IL-6, IL-10

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