Lung inflammation and interstitial fibrosis by targeted alveolar epithelial type I cell death.

Sandra Carignon, Dorian De Moura Rodrigues,David Gosset,Elodie Culerier,Sarah Huot-Marchand,Florence Savigny,Eric Kaya,Valerie Quesniaux,Aurélie Gombault,Isabelle Couillin,Bernhard Ryffel,Marc Le Bert,Nicolas Riteau

Frontiers in immunology（2023）

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摘要

Together, we demonstrate that depletion of AT1 cells using repeated injury represents a novel approach to investigate chronic lung inflammatory diseases and to identify new therapeutic targets.

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关键词

AT1 cell depletion,sterile inflammation,lung injury,iDTR,cell death

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