Demethylating agents in combination with CD7-targeted CAR-T for the successful treatment of a case with mixed-phenotype acute leukemia relapsed after allogeneic hematopoietic stem cell transplantation: A Case Report.

Ying Han, Hao Yao,Guang-Cui He,Si-Han Lai,Yan Deng,Shan Zhang, Ying He,Yi-Song Xiong,Alex H Chang,Yi Su,Hai Yi

Frontiers in immunology（2023）

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摘要

Demethylating drugs combined with CD7-targeted CAR-T cell therapy is feasible in treating MPAL patients with relapse after transplantation, with good efficacy and safety, which will be a promising treatment option for MPAL.

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关键词

mixed-phenotype acute leukemia, demethylating agent, CD7-targeted, chimeric antigen receptor-t cell therapy, allogeneic hematopoietic stem cell transplantation, demethylate

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