A simplified two-marker immunohistochemistry strategy for Lynch syndrome screening in endometrial cancer patients.

Ala Aiob,Yeo Rae Kim,Kidong Kim,Hyojin Kim,Yong Beom Kim,Duck Woo Kim,Jae Hong No,Soo Hyun Seo,Dong Hoon Suh,Kyoung Un Park

Obstetrics & gynecology science（2023）

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摘要

Lynch syndrome screening using MSH6 and PMS2 IHC-initiated cascade testing is a viable strategy in the management of endometrial cancer. A simplified strategy (MSH6 and PMS2 IHC→germline MMR gene sequencing) was proposed because most women with MMR deficiencies exhibited high MSI.

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关键词

lynch syndrome ii,mass screening,g-t mismatch-binding protein,immunohistochemistry

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