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Prospective Assessment of Bone Metabolism Biomarkers and Survival in Metastatic Castration-resistant Prostate Cancer Patients Treated with Radium-223: The PRORADIUM Study

Nuria Romero-Laorden,David Lorente,Guillermo de Velasco,Rebeca Lozano, Bernardo Herrera,Javier Puente,Pedro P. López,Ana Medina,Elena Almagro,Enrique Gonzalez-Billalabeitia, Jose Carlos Villla-Guzman,Aránzazu González-del-Alba,Pablo Borrega,Nuria Laínez, Ana Fernández-Freire,Amaia Hernández,Alejo Rodriguez-Vida,Isabel Chirivella,Eva Fernandez-Parra,Fernando López-Campos

European Urology Oncology（2023）

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Abstract
In this prospective cohort of 169 metastatic castration-resistant prostate cancer patients treated with radium-223, bone alkaline phosphatase shows prognostic value to identify patients more likely to live beyond 2 yr after treatment with Ra-223. Its predictive value remains to be assessed.
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Key words
Metastatic prostate cancer,Radium-223,Biomarkers,Bone alkaline phosphatase
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