The interplay between -Synuclein and NLRP3 inflammasome in Parkinson's disease

alpha-Synuclein is a member of a protein of synucleins, which is a presynaptic neuron protein. It is usually highly expressed in the brain and participates in the formation and transmission of nerve synapses. It has been reported that abnormal aggregation of alpha-Syn can induce the activation of NLRP3 inflammasome in microglia, increase the production of IL-113, and aggravate neuroinflammation. Therefore, it is recognized as one of the important factors leading to neuroinflammation in Parkinson's disease. In this paper, we aimed to explore the influence of post translational modification of alpha-Syn on its pathological aggregation and summarize various pathways that activate NLRP3 triggered by alpha-Syn and targeted therapeutic strategies, which provided new insights for further exploring the origin and targeted therapy of Parkinson's disease.