Genotoxic Effects of New Azoloazine Derivatives with Antitumor Activity in MCF-7 Tumor Cell Culture

The genotoxic properties of three new azoloazine derivatives (azoloazines 1 – 3 ) exhibiting cytotoxic activity were studied in an in vitro experiment using MCF-7 human breast cancer cell culture. Acomparison of the effects of azoloazines 1 – 3 at doses of 1/2, 1/10, and 1/50 of IC 50 with those of epirubicin at the same doses on the main indicators of damage to the genetic apparatus of the cells revealed that the studied compounds had the greatest toxic effect on DNAat a dose 1/10 of IC 50 . The genotoxicity of azoloazines 1 – 3 at a dose 1/10 of IC 50 was shown to exceed that of epirubicin.