Multi-Omic Candidate Screening for Markers of Severe Clinical Courses of COVID-19.

Alexander Dutsch, Carsten Uhlig,Matthias Bock, Christian Graesser,Sven Schuchardt,Steffen Uhlig,Heribert Schunkert,Michael Joner,Stefan Holdenrieder,Katharina Lechner

Journal of clinical medicine（2023）

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摘要

Our novel prediction model identified biological and regulatory candidate networks preceding hyperinflammation and coagulopathy, with the most promising group being the proteins that explain changes in D-dimers. These biomarkers need validation. If causal, our work may help predict disease courses and guide personalized treatment for COVID-19.

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关键词

predictive diagnostics,COVID-19 longitudinal disease course,hyperinflammation,COVID-19 coagulopathy,candidate screening,multi-omics

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