HIV-1 subtypes maintain distinctive physicochemical signatures in Nef domains associated with immunoregulation.

Susanna L Lamers,Gary B Fogel,Enoch S Liu,David J Nolan,Rebecca Rose,Michael S McGrath

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases（2023）

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摘要

Recent studies have focused on HIV Nef as a driver of immunoregulatory disease in those HIV infected and on ART. Nef acts through a complex mixture of interactions that are directly linked to the key features of the subtype-specific domains we identified with the ENN. The study supports the hypothesis that varied Nef subtypes contribute to subtype-specific disease progression.

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关键词

HIV,Nef protein,Machine-learning,Bioinformatics,HIV subtypes,Sequence analysis

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