Clinical Characterization, Course, and Treatment of Othello Syndrome: A Case Series and Systematic Review of the Literature

Background: Othello syndrome (OS) is a condition characterized by a delusion of jealousy that one's spouse is having extramarital affairs. As in the eponymous Shakespearean tragedy, there is an unfortunate risk of violence. For patients with these symptoms, consultationliaison psychiatrists may be asked to assist with evaluating the differential diagnosis, assessing safety, and developing treatment options. Objective: This study's objective was to solidify current knowledge of the clinical presentations and management of OS through a systematic review of the literature and description of 2 new cases. Methods: We conducted a literature search from the start of relevant databases through August 2023 to identify English language case reports of adults ($18 years) with OS that described clinical evaluations, biological treatments, and outcomes. We extracted demographics, proposed etiologies, treatment choices and responses, duration of delusions, comorbid psychiatric symptoms, neuro-radiographic findings, and presence of physical violence. We reported clinical findings for 2 new cases. Results: Following Preferred Reporting Items for Systematic Reviews and Meta -Analyses guidelines, we screened 705 abstracts and conducted full -text reviews of 118 articles to identify 73 cases published from 1983 to 2023 meeting inclusion criteria. The mean age was 58.2 years with male predominance (M.center dot F = 1.88). Etiologies included primary psychiatric disorders (16, 22%), other medical conditions (38, 52%), and medications or other substances (19, 26%). Delusional disorder, cerebrovascular accident, and dopaminergic agonists were the most common etiologies, respectively, in these groups. Antipsychotics were the most common treatment (57, 78%). Symptom remission was reported in 51 (70%) cases. The average duration of OS was 39.5 months. Of 32 cases reporting brain imaging insults, 12 of 20 (60%) showed right -sided lesions, and 8 of 20 (40%) showed left -sided lesions, with 9 of 32 (28%) located in the frontal lobes. The most commonly co -existing psychiatric symptom was depression (14, 19%). Violence was reported in 25 cases (34%). Our 2 new cases were consistent with these findings. Conclusions: OS may be a manifestation of several neuropsychiatric conditions, primarily delusional disorder, cerebrovascular accident, Alzheimer's dementia, and the use of dopaminergic agonists. One-third of cases include violent behaviors. It appears to respond to antipsychotic medications, but treatment is delayed more than 3 years on average. Available data have not localized OS to a specific brain region. (Journal of the Academy of Consultation -Liaison Psychiatry 2024; 65:89-105)