A stochastic model of blood flow to calculate blood dose during radiotherapy.

Chris Beekman,Julia D Withrow,Camilo M Correa Alfonso,Shreya Pathak,Robert J Dawson,Natalia Carrasco-Rojas, Andrew Sforza,Carlos Colon,Wesley E Bolch,Clemens Grassberger,Harald Paganetti

Physics in medicine and biology（2023）

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摘要

The ability to report the blood dose distribution during radiotherapy is imperative to test and act upon the current paradigm that radiation-induced lymphopenia is caused by direct cell killing of lymphocytes in the blood. We have built a general model that can do so for various treatment sites. The presented framework is publicly available at https://github.com/mghro/hedos.

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关键词

Weibull distribution,blood dose,blood flow,organ vasculature,stochastic compartment model,tranfer function

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