T7 expression plasmids for producing a recombinant human G1P[8] rotavirus comprising RIX4414 sequences of the RV1 (Rotarix , GSK) vaccine strain

Asha A. Philip,Chantal A. Agbemabiese,Guanghui Yi,John T. Patton,Jelle Matthijnssens

MICROBIOLOGY RESOURCE ANNOUNCEMENTS（2023）

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摘要

The live oral rotavirus RV1 (Rotarix) vaccine is formulated from the human G1P[8] RIX4414 virus. Based on RIX4414 sequences, T7 expression plasmids were constructed that supported recovery of recombinant RIX4414-like viruses by reverse genetics. These plasmids will advance the study of the RV1 vaccine, possibly allowing improvements to its efficacy.

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rotavirus, reverse genetic analysis, vaccines, RIX4414 virus, recombinant virus

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