Circulating alternative pathway complement cleavage factor Bb is associated with vascular lesions and outcomes in IgA nephropathy.

Gabriel Ștefan,Perrine Jullien,Ingrid Masson,Eric Alamartine,Christophe Mariat,Nicolas Maillard

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association（2023）

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摘要

Serum Bb fragment concentration at diagnosis may predict long-term IgAN outcomes, potentially due to AP activation at the endothelial surface. Further research is needed to confirm these results and evaluate Bb fragment's role in IgAN management.

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关键词

alternative pathway, Bb fragment, immunoglobulin A nephropathy, kidney survival, vascular lesions

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