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Plasma proteoglycan 4: a novel biomarker for acute lung injury after pediatric cardiac surgery.

Ahmed Asfari, Erica A Doyle,Gregory D Jay,Natalia Aristizabal,Ananya Manchikalapati,A K M Fazlur Rahman,Kristal M Hock,Santiago Borasino,Namasivayam Ambalavanan,Tannin A Schmidt,Leslie A Rhodes

Translational pediatrics（2023）

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Abstract
Lower levels of plasma PRG4 is associated with longer duration of mechanical ventilation, worse ventilator compliance and higher oxygen requirement after cardiac surgery in our patient population. Further validation of this finding in a larger and more diverse patient population is necessary prior to its application at the bedside.
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Key words
Acute lung injury (ALI), proteoglycan 4 (PRG4), pediatric cardiac surgery, infants, biomarkers
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