High prevalence of liver fibrosis and cirrhosis in a nationwide sample of organ donors with liver histology.

We appreciate Devarbhavi et al’s dedicated and comprehensive review of the global liver disease burden. [1] Devarbhavi H. Asrani S.K. Arab J.P. Nartey Y.A. Pose E. Kamath P.S. Global burden of liver disease: 2023 update. J Hepatol. 2023; 79: 516-537 Abstract Full Text Full Text PDF PubMed Scopus (20) Google Scholar Global burden of liver disease: 2023 updateJournal of HepatologyVol. 79Issue 2PreviewLiver disease accounts for two million deaths annually and is responsible for 4% of all deaths (1 out of every 25 deaths worldwide); approximately two-thirds of all liver-related deaths occur in men. Deaths are largely attributable to complications of cirrhosis and hepatocellular carcinoma, with acute hepatitis accounting for a smaller proportion of deaths. The most common causes of cirrhosis worldwide are related to viral hepatitis, alcohol, and non-alcoholic fatty liver disease. Hepatotropic viruses are the aetiological factor in most cases of acute hepatitis, but drug-induced liver injury increasingly accounts for a significant proportion of cases. Full-Text PDF