Simulation-driven optimization of insulin therapy profiles in a commercial hybrid closed-loop system

•An Identification-Reproduction-Optimization (IRO) approach is proposed to gradually and safely optimize insulin therapy profiles for Control-IQ.•Use of reliable simulations to reproduce real-world data and shorten the insulin treatment optimization process.•User-specific diabetes records are used to generate virtual images that account for non-modeled phenomena.•The IRO method improved glucose control over time by reducing the risks of hypo- and hyperglycemia.