Real-World Glycemic Outcomes of > 5,900 Adults with Type 1 Diabetes Using the Omnipod 5 Automated Insulin Delivery (AID) System with Cloud-Based Data Management

The Omnipod 5 AID System is a novel tubeless hybrid closed-loop system that allows for personalized therapy through customizable glucose targets from 110-150mg/dL in 10mg/dL increments. The System enables automatic upload of data for all users initiating the system, facilitating unprecedented access to evaluate real-world outcomes. Continuous glucose monitoring (CGM) and insulin data from Omnipod 5 users with type 1 diabetes (T1D) aged ≥18y in the US with ≥90 days of data available in the cloud-based data management system were included. Data from 5,968 users with sufficient CGM data (≥75% of days with ≥220 readings) and using the lowest target (110mg/dL) for ≥50% of the time, aged 18 to 25y (n=840), 26 to 49y (n=3,127), 50 to 64y (n=1,423), and ≥65y (n=578) were available at the time of analysis. Users were aged mean±SD 42.8±15.0y with median 139 days of system use. Outcomes are shown in the Table for each age group. Median time in target range (70-180mg/dL) was 69.6%, 73.0%, 74.2%, and 77.4% for each age group, respectively. Time <70mg/dL in each age group was low: median 1.0%, 1.0%, 1.0%, and 0.9%, respectively. These results are the first to demonstrate that in over 5,900 adults using the Omnipod 5 System in a real-world setting, highly favorable glycemic outcomes are achievable and are similar to those first reported in a pivotal trial. Disclosure R.Lal: Advisory Panel; Provention Bio, Inc., Consultant; Abbott Diabetes, Biolinq, Capillary Biomedical, Inc., Deep Valley Labs, Gluroo, Tidepool, PhysioLogic Devices, Morgan Stanley. G.Aleppo: Advisory Panel; Medscape, Consultant; Bayer Inc., Insulet Corporation, Research Support; Dexcom, Inc., Eli Lilly and Company, Emmes, Insulet Corporation, Fractyl Health, Inc., WellDoc, Speaker's Bureau; Dexcom, Inc. L.M.Huyett: Employee; Insulet Corporation, Stock/Shareholder; Insulet Corporation. K.Snow: Employee; Insulet Corporation. J.J.Mendez: None. I.Hadjiyianni: Employee; Insulet Corporation, Stock/Shareholder; Insulet Corporation, Eli Lilly and Company. T.T.Ly: Employee; Insulet Corporation. Funding Insulet Corporation