Synthesis, Characterization and Anticancer Molecular Docking Studies of Phenothiazine Derivatives - A Green Chemical Approach

Phenothiazines are antipsychotic drugs that have been studied for millennia. In addition to its fundamental neuroleptic properties, phenothiazines have attracted study attention for their anticancer properties. To develop powerful anticancer medications, we have concentrated on a variety of phenothiazine designs. In this study, we used a single step multicomponent reaction of N-alkyl-3-formyl phenothiazine under reflux/ultrasonic conditions to produce a range of heterocyclic derivatives containing phenothiazine molecules. To characterize the structures of novel compounds, IR, 1H-NMR, 13C-NMR, and mass spectral data were utilized. Utilizing different cancer cell proteins, all the derivatives were investigated for their potential as anticancer molecules. Phenothiazine moiety is described as a group of highly significant compounds with a broad range of biological actions in the scientific literature. Several phenothiazine base heterocyclic compounds were created using one-pot synthesis and their molecular docking was studied. For all cancer cell proteins except 2DSQ, docking data showed compound 3 a had the highest negative dock score.image