Synthetic Strategies for the Construction of Indolizines and Indolizine-fused Compounds: Thienoindolizines and Indolizinoindoles

This paper provides a review on various methodologies developed for the synthesis of different indolizine derivatives and an overview of their application. These include thienoindolizine and indolizino[8,7-b]indole derivatives. The indolizine nucleus occurs as privileged scaffold of many natural and synthetic molecules with significant biological activity. Fused-indolizines such as thienoindolizines and indolizinoindole derivatives are of great interest, due to their antitumor, antimicrobial and enzyme inhibitor activity. Because of their widespread use in chemical, medicinal, biological, and materials science research, indolizines and their fused derivatives are attractive synthetic targets in the search for efficient methods for their construction. The approaches to the synthesis, properties and application of various indolizine derivatives and its fused derivatives such as thienoindolizines and indolizinoindoles are summarized in this review. The study focuses on the recent articles on the topics of indolizines and indolizino[8,7-b]indoles continuing previous works as well as it includes a general review on thienoindolizine derivatives.image