Relationships between the structural characteristic of curcumins that affect cell proliferation of hepatocarcinoma cells.

Relationships between the structural characteristic of curcumin and dimethoxycurcumin and their antitu-moral activity were studied. Treatment of HepG2 cells for 24 h with the curcumin and dimethoxycurcumin resulted in apoptosis induction and dose-dependent in-hibition of cell proliferation. The calculated docking and the DFT method, suggest a structure-activity relation-ship between the activities of dimethoxycurcumin and curcumin structure and the apoptosis in HepG2 cells.