Synthesis and Antimicrobial Activity of Hexahydrochromeno[4,3- d ]pyrimidine-2-thiones Thiouronium Salts

E. S. Makarova, A. A. Romanycheva, M. V. Blyumina,A. A. Shetnev,S. I. Filimonov

RUSSIAN JOURNAL OF GENERAL CHEMISTRY（2023）

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Abstract

The thiouronium salts of chromeno[4,3- d ]pyrimidine-2-thiones were isolated as individual diastereomers and characterized by 1 H, 13 C NMR spectroscopy and mass spectrometry data. Antibacterial and antifungal activity against sensitive strains of gram-negative ( E. coli and P. fluorescens ) and gram-positive bacteria ( S. aureus ), and C. albicans fungi was studied.

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Key words

thioureas,chromenes,chromeno[4,3-d]pyrimidine-2-thiones,S-alkylation,antimicrobial activity

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