Identification of novel 4-thiazolidinones as new TcaR inhibitors: Design, synthesis, molecular docking, MD simulation, ADMET and in vitro antibacterial evaluation

•Novel 4-thiazolidinone hybrids were synthesized using multi-component reaction.•The synthesized compounds exhibited significant in vitro antibacterial activity against a variety of gram-positive and gram-negative strains.•The hybrids demonstrated significant binding interactions with the TcaR inhibitors.•The novel analogs showed notable pharmacokinetic proficiency according to in silico ADMET analysis.