Impact of highly effective modulator therapy on chronic rhinosinusitis and health status: 2-year follow-up

Daniel M. Beswick,Aastha Khatiwada,Jessa E. Miller,Stephen M. Humphries,Alexandra Wilson,Eszter K. Vladar,David A. Lynch,Jennifer L. Taylor-Cousar

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society（2023）

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摘要

•HEMT improves multiple measures of sinusitis through 2 years of therapy in adults.•Sinus CT scans analyzed via machine learning methods and sinus symptoms improved.•Health utility increased and productivity loss decreased with 24 months of HEMT.•HEMT initiated in adulthood did not fully resolve chronic rhinosinusitis in adults.

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关键词

Cystic fibrosis,Chronic rhinosinusitis,Machine learning,Highly effective modulator therapy,Computed tomography,Quality of life

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