Gabapentin alleviated the cough hypersensitivity and neurogenic inflammation in a Guinea pig model with repeated intra-esophageal acid perfusion.

Haopeng Zhi,Mingyu Zhong,Junfeng Huang,Ziwen Zheng, Xiaolong Ji, Yilin Xu,Junguo Dong,Wenbo Yan,Zhe Chen,Chen Zhan,Ruchong Chen

European journal of pharmacology（2023）

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摘要

Gabapentin can desensitize the cough sensitivity in the GERC model of guinea pig. The anti-tussive effect is associated with the alleviated peripheral neurogenic inflammation as reflected in the decreased level of SP.

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关键词

cough hypersensitivity,gabapentin,neurogenic inflammation,intra-esophageal

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