Individual and combined effects of cadmium and lead exposure in rats.

The exposure of humans and animals to environmental compounds is rarely restricted to a single chemical. Cadmium (Cd) and lead (Pb) are two heavy metals known to be the most toxic. Deleterious effects of each metal alone are well documented. Unfortunately, very few studies were conducted to determine their combined effect. Four groups of Wistar rats were treated intravenously for 15 days. The control group received physiological saline solution; groups 2 and 3 were treated with Cd chloride and lead acetate, respectively ; and the treatment group 4 received a combined treatment of Cd and Pb . A significant decrease was recorded for hematological parameters , with an increase in white blood cells and an inhibition in δ-ALAD level. Cell injury in the livers and kidneys was clearly shown by the significant elevation of the biochemical markers. Cd and Pb induced oxidative stress and had adverse health effects at lower exposure levels than previously thought.