The lipid Gb3 promotes germinal center B cell responses and anti-viral immunity.

Pankaj Sharma,Xiaolong Zhang,Kevin Ly,Yuxiang Zhang,Yu Hu,Adam Yongxin Ye,Jianqiao Hu,Ji Hyung Kim, Mumeng Lou,Chong Wang,Quinton Celuzza,Yuji Kondo,Keiko Furukawa,David R Bundle,Koichi Furukawa,Frederick W Alt,Florian Winau

bioRxiv : the preprint server for biology（2023）

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摘要

Gb3 abundance on GC B cells selects antibodies with high affinity and broad epitope reactivities, which are cross-protective against heterologous influenza infection.

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