Novel function of MOTS-c in mitochondrial remodelling contributes to its antiviral role during HBV infection.

Caorui Lin,Linjie Luo,Zhen Xun,Chenggong Zhu,Ying Huang,Yuchen Ye,Jiawei Zhang,Tianbin Chen,Songhang Wu,Fuguo Zhan,Bin Yang,Can Liu,Ning Ran,Qishui Ou

Gut（2023）

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Abstract

MOTS-c has the potential to serve as a biomarker for the progression of HBV infection while also enhancing antiviral efficacy. These findings present a promising innovative approach for effectively treating patients with CHB. Furthermore, our research uncovers a novel role for MOTS-c in regulating MYH9-actin-mediated mitochondrial dynamics and contributing to mitochondrial biogenesis.

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Key words

hepatitis B, chronic viral hepatitis, diagnostic virology, antiviral therapy

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