Therapeutic Effect of Nicotinamide Mononucleotide for Hypoxic-Ischemic Brain Injury in Neonatal Mice.

Takuya Kawamura, Gagandeep Singh Mallah,Maryam Ardalan,Tetyana Chumak,Pernilla Svedin,Lina Jonsson,Seyedeh Marziyeh Jabbari Shiadeh, Fanny Goretta,Tomoaki Ikeda,Henrik Hagberg,Mats Sandberg,Carina Mallard

ASN neuro（2023）

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摘要

Neonatal hypoxia-ischemia reduces nicotinamide adenine dinucleotide (NAD) and SIRT6 levels in the injured hippocampus.Hippocampal high mobility group box-1 (HMGB1) release is significantly increased after neonatal hypoxia-ischemia.Nicotinamide mononucleotide (NMN) treatment normalizes hippocampal NAD and SIRT6 levels, with significant decrease in caspase-3 activity and HMGB1 release.NMN improves early developmental behavior, as well as motor and memory function.

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关键词

nicotinamide mononucleotide,hypoxic–ischemic brain injury,neonatal mice,therapeutic effect

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