Type 1 Interferon-Stimulated Gene Expression and Disease Activity in Pediatric Rheumatic Diseases: No Composite Scores Needed?

Christina Weiden,Melanie Saers,Tobias Schwarz,Tanja Hinze,Helmut Wittkowski,Christoph Kessel,Katja Masjosthusmann,Michael Mohr,Georg Evers,Sandra Oesingmann-Weirich,Dirk Foell,Claas H Hinze

ACR open rheumatology（2023）

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摘要

In a real-world cohort, individual ISG expression levels robustly reflected clinical disease activity in CTD and IFNP, especially in JDM, which would simplify such analyses in clinical routine and be more cost-effective. Threshold levels varied across diseases, potentially reflecting different mechanisms of type 1 IFN overactivation.

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pediatric rheumatic diseases,rheumatic diseases,gene expression,<scp>interferon‐stimulated</scp>,composite scores

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