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Analysis of the Measured FDG Uptake from the First-in-Human Clinical Trial of Biology-Guided Radiotherapy.

M Surucu,L Vitzthum,D T Chang,M F Gensheimer,N Kovalchuk,B Han,A H Iagaru,A Da Silva,M Narayanan,D Aksoy,K Feghali,S M Shirvani,A Maniyedath,B Cai,A Pompos,T Dan,O K Öz,P Iyengar,R D Timmerman,A Garant

International journal of radiation oncology, biology, physics（2023）

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Abstract
The dual PET arcs and limited axial extent of the X1 PET subsystem results in lower system sensitivity in comparison to diagnostic PET scanners equipped with full ring and larger axial extent, as expected. With the same FDG injection, the RefleXion X1 produced SUVmax values that were 30.4 % of the diagnostic PET/CT scanners' values. Nevertheless, the X1 collected sufficient emission data to enable successful completion of emulated BgRT deliveries that met dose accuracy criteria in a clinical setting.
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