Focused Ultrasound for Blood-Brain Barrier Opening and Delivery of Anti-PD1 in Diffuse Midline Gliomas

D. Kokossis,H.J. Wei, M. Gallitto,N. Yoh, N. McQuillan,M. Tazhibi, X. Berg,X. Zhang,L. Szalontay,R. Gartrell, P. Jovana,Z. Zhang,A. Molotkov,A. Mintz, E.E. Konofagou,C.C. Wu

International journal of radiation oncology, biology, physics（2023）

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摘要

Our results support that FUS-mediated BBBO can increase treatment efficacy of anti-PD1 in a DMG murine model, due to improved targeted delivery to the tumoral region after systemic antibody administration. We consider these findings strong rationale for further investigation of the therapeutic effects of combinatorial treatment using FUS-mediated BBBO and ICIs for the treatment of DMG.

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diffuse midline gliomas,ultrasound,blood-brain

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