Evaluating the Utility of Traditional Bowel Dose Constraints when Treating Abdominal and Pelvic Sarcomas with Preoperative Radiation Therapy

Traditional volumetric bowel bag dose constraints are frequently exceeded given the large size of AP-STS at presentation and thus the large RT target volumes. Despite a significant proportion of patients exceeding these constraints, these data suggest that RT is overall well-tolerated, and the risk of developing toxicities does not correlate with traditional bowel bag volumetric constraints. There are ongoing efforts to substantially expand this cohort for further investigation into the relationship between dosimetric data and bowel toxicities in order to identify more predictive bowel constraints that can be used during treatment planning of AP-STS.