Association between Liver Metastases and Treatment Response in Patients with Metastatic, Microsatellite Stable Colorectal Cancer Treated with Radiation Therapy and Dual Immune Checkpoint Blockade.

J L Koenig, L Pappas,B Y Yeap,J W Clark,J N Allen,J Y Wo,D P Ryan,L S Blaszkowsky,B Giantonio,C Weekes,S Klempner,H J Roberts,L C Drapek,L Ly, J Meurer,R Corcoran, A Mehta,D Ting,T S Hong,A R Parikh

International journal of radiation oncology, biology, physics（2023）

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摘要

Among patients with metastatic MSS CRC treated with ICIs and RT in two phase 2 studies, ORR, DCR, and OS are significantly higher in patients without liver metastases. Liver-directed RT may improve ICI efficacy and OS in patients with liver metastases. Further analysis of PFS and prospective study of ICIs with comprehensive liver-directed RT are warranted.

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