CDC73 Impairment of MAPK1 Ubiquitination and Activation of the Mtor Signaling Pathway

H. Zhang, Y. Gao, M. Du, E. Pan,X. Wang,X. Zhang

International journal of radiation oncology, biology, physics（2023）

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摘要

CDC73 promoted MAPK1 ubiquitination and degradation so that affected MAPK1 level and subsequently led to breast cancer progression, providing a novel therapeutic strategy to combat cancer.

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关键词

Breast cancer,CDC73,MAPK1,ubiquitination mTOR signaling pathway.

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