Comparison of Tumor Control between FLASH and CONV in an Orthotopic Breast Cancer Model.

S Melemenidis, V Viswanathan, S Dutt,R Manjappa,M R Ashraf,L A Soto,L Skinner, S J Yu,M Surucu,E E Graves,B Loo,F M Dirbas

International journal of radiation oncology, biology, physics（2023）

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摘要

FLASH was as effective as CONV in controlling growth and eradicating murine BC. Based on other preclinical studies, single-fraction doses between 20 and 30Gy, as well as hypofractioned RT schedules, may identify FLASH doses that achieve comparable tumor control with less toxicity than CONV. Such findings would encourage clinical trials of FLASH in human BC.

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