Radiotherapy Resistance in Prostate Cancer Cells: AKR1C3 Inhibition of Ubiquitinated Degradation of Nrf2 through Interaction with KEAP1

F. Lyu, X. Gao, S. Shang, S. Li, X. Ren, J. Chen

International journal of radiation oncology, biology, physics（2023）

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摘要

In sum, we found that AKR1C3 can bind with Keap1 leading to reduced ubiquitination level of Nrf2, causing upregulation of Nrf2 expression and providing new insights into PCa radiotherapy resistance.

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关键词

akr1c3 inhibition,prostate cancer cells,prostate cancer,radiotherapy,nrf2

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