Experimental Investigation of Lung Toxicity after Radiation Therapy Combined with Immune Checkpoint Inhibitors.

To the best of our knowledge, this is the first experimental study to find that the combination of RT with ICIs has an impact on the risk of pulmonary fibrosis. Strikingly, ICIs (a-PD1 + a-CTLA4) combined with unfractionated RT resulted in increased lung damage, while concomitant use of ICIs (a-PD1 + a-CTLA4) with fractionated RT resulted in reduced lung toxicity. In the field of radioimmunotherapy, such studies are of great value for the interpretation of clinical studies and of importance for the design of further clinical trials.