Clinical Outcomes Following an Initial Stereotactic Radiosurgery Course for Brain Metastases from Melanoma.

J X Leng, C C Huang, J J Qazi,D J Carpenter, B D Natarajan,M Arshad,M Ferreira, O Schultz,M J Moravan, T C Mullikin,Z J Reitman,J P Kirkpatrick,S R Floyd,A K S Salama, P Fecci,S J Chmura, J C Hong, J K Salama

International journal of radiation oncology, biology, physics（2023）

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Abstract

In this modern, multi-institutional cohort of SRS patients, melanoma BM patients had worse FFICP compared to non-melanoma BM patients, and BRAFmut patients had worse FFICP than BRAFwt patients. RN was associated with mutational status and receipt of TT pre-SRS. OS did not vary significantly across groups. This analysis may help inform systemic therapy decisions and future genomic studies for patients with BMs from melanoma.

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