Assessment of Minimum Dose as a Strong Predictor of Local Failure after Spine SBRT

R.O. Kowalchuk, T.C. Mullikin, G.M. Spears,P.S. Rose, B.L. Siontis, D.K. Kim,B.A. Costello,J.M. Morris,R.W. Gao, S. Shiraishi, J. Lucido,K. Olivier,D. Owen,B.J. Stish,M.R. Waddle, N.N. Laack II, S.S. Park,P.D. Brown,K.W. Merrell

International journal of radiation oncology, biology, physics（2023）

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摘要

Spine SBRT offers favorable local control using a range of dose-fractionation schemes; however, minimum dose has a strong association with local control, unlike any other dosimetric factors tested. Furthermore, statistical significance was maintained even when considering epidural extension and potential limitations from dose to the spinal cord. Our data suggests that the minimum dose should be prioritized during treatment planning, ideally to at least 14 - 15.8 Gy for single fraction.

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关键词

spine sbrt,minimum dose,local failure

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