Safety and Efficacy of Stereotactic Radiosurgery with Concurrent Targeted Systemic Therapy for Brain Metastases

J. Hall,K. Wang, K. P. Lui, R. Darawsheh, J. W. Shumway,L. A. Carey,K. Reeder Hayes, C. B. Lee,S. Moschos, S. Sengupta, R. Chaudhary, L. Yogendran, T. D. Struve, R. E. Vatner, L. E. Pater,J. C. Breneman, A. A. Weiner,C. Shen

International journal of radiation oncology, biology, physics（2023）

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摘要

Although heterogeneous, patients treated with SRS/SRT and ongoing CNS-active targeted systemic therapies have on average >6 month intracranial PFS and little evidence of significant toxicity. We observed <6% G2+ radiation necrosis for this cohort, and no particular class of agent was associated with a significantly higher rate of G2+ radiation necrosis.

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关键词

stereotactic radiosurgery,brain metastases,concurrent targeted systemic therapy

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