30 Gy vs. 45 Gy Consolidative Thoracic Radiation (cTRT) for Extensive Stage Small Cell Lung Cancer (ES-SCLC): A Multicenter, Randomized, Phase 3 Trial.

N Bi, L Deng,X Hu, G Shayan, L Zhao, L Zhang,W Jiang,J Zhang,X Zhu, Y Wang,H Ge, J Cao, Q Lin, M Chen,L Wang

International journal of radiation oncology, biology, physics（2023）

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摘要

This randomized trial did not find a higher probability of survival improvement in patients with ES-SCLC receiving cTRT of 45 Gy in 15 fractions compared with 30 Gy in 10 fractions. In contrast, there was an increase in toxicity, especially radiation pneumonitis. Additional randomized studies investigating the role of cTRT in ES-SCLC after a response to chemoimmunotherapy are warranted.

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