Radiation Therapy Sensitizes Head-and-Neck Cancer Cells to Killing by Chimeric Antigen Receptor (CAR)-NK Cells Targeting CD70

G. S. Manzar,H. Rafei,B. Kumar,M. Shanley,S. Acharya, B. Liu, A. Xu, X. A. Wang, S. Islam,M. Kaplan, R. Basar, N. Uprety, R. Shrestha, L. Melo Garza,Y. Li,P. P. Banerjee,M. T. Spiotto,B. Dabaja,K. Rezvani,M. Daher

International journal of radiation oncology, biology, physics（2023）

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摘要

This work represents the first preclinical study to identify the synergy of RT and CAR-NK cell therapy in solid tumors and is the first demonstration of CAR-NK cell activity against human HNSCCs. We show significantly enhanced potency of CAR-NK cells against irradiated tumor cells in vitro. Collectively, this research will be vital to guide efforts expanding into other target antigens and tumor types.

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关键词

radiation therapy,chimeric antigen receptor,cancer,head-and-neck

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