Long-Term Outcomes of De-Intensified Chemoradiotherapy for Human Papillomavirus-Associated Oropharyngeal Squamous Cell Carcinoma

R. Morse, B. Beaty, D. H. Moon, R. Green, V. Xu,J. Weiss,S. Sheth,S. Patel, J. Blumberg,T. Hackman, C. Lumley,S. Patel,W. Yarbrough, S. B. Huff, M. C. Repka,R. Dagan,R. J. Amdur, B. S. Chera,C. Shen, X. Chen

International journal of radiation oncology, biology, physics（2023）

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摘要

Dose de-intensification of 60 Gy radiotherapy with weekly cisplatin results in favorable long-term tumor control in patients with HPV-associated OPSCC. De-intensified 60 Gy alone may be efficacious in carefully selected patients with T0-T2 N0-1 (AJCC 7th edition) disease. Inclusion of biologically favorable patients with more extensive former smoking history in de-intensification clinical trials may be warranted.

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chemoradiotherapy,oropharyngeal squamous cell,carcinoma,long-term,de-intensified,papillomavirus-associated

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