Direct infection of SARS-CoV-2 in human iPSC-derived 3D cardiac organoids recapitulates COVID-19 myocarditis

Weijie Wang,Jinxuan Yang,Pinfang Kang,Jinsong Bai,Xiaoli Feng, Liuqi Huang,Yiming Zhang, Yuechun Wu,Bi Tang,Hongju Wang, JianJie Jiang,Minghua Li,Bing Zhao,Xinglou Yang

VIROLOGICA SINICA（2023）

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摘要

•Establishment of 3D cardiac organoids composed of cardiomyocyte and endothelial layers.•SARS-CoV-2 infection causes multi-lineage cardiac injuries.•Cardiovascular health should be greatly concerned in COVID-19 patients.

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